tablets for covid 19 patients

Emergency use authorization. Like all antivirals, Paxlovid works best early in the course of an illnessin this case, within the first five days of symptom onset, says Jeffrey Topal, MD, a Yale Medicine infectious diseases specialist who is involved in determining COVID-19 treatment protocols for Yale New Haven Hospital patients. Continue wearing a mask for a total of 10 days after your rebound symptoms started. WebMD does not provide medical advice, diagnosis or treatment. Monoclonal antibody treatment is given by infusing the material into the bloodstream. If additional studies suggest that Covid symptoms are more likely to rebound after a five-day course of Paxlovid, federal officials and health care providers may need to consider longer or repeated courses of antivirals. Convalescent plasma with high antibodies may be used to treat some hospitalized people with COVID-19 who are either early in their illness or have weakened immune systems. Some antivirals prevent viruses from spreading to healthy cells by blocking the receptors on cell surfaces. Signs of this potentially fatal complication. The COVID-19 infection has two phases: replication and inflammation. Treatments for coronavirus (COVID-19) The NHS offers treatments to people with coronavirus (COVID-19) who are at the highest risk of becoming seriously ill. Effective antiviral treatments can shorten the duration of the illness and lessen complications for some people. First approved by the FDA in 2020 for COVID-19 patients requiring hospitalization, . Stay home (or isolate) for at least 5 days. If test results say you still have COVID after 10 days, talk to your doctor. How do I get antiviral pills for Covid-19? Dexamethasone may be processed differently in Black patients than in other patients. On Oct. 22, 2020, theFDA approved the drugfor treatment of hospitalized adult and pediatric patients with suspected or laboratory-confirmed COVID-19, whether the illness is mild or severe. All rights reserved. What you need to know from Johns Hopkins Medicine. There is only one product approved by the U.S. Food and Drug Administration (FDA) to treat coronavirus disease 2019 (COVID-19). The second drug, called molnupiravir, was developed by Merck and was granted emergency use authorization just one day after the Pfizer treatment in December. Oral administration of FNC in rats revealed . The white tablets each contain 100 mg of ritonavir. The Food and Drug Administration has also cleared an intravenous antiviral medication from Gilead Sciences called Veklury (remdesivir), but it is most often administered at a clinic or infusion center. This can be done at home, at a regular health care providers office, at a testing site or at one of the pharmacy chains, community health centers, long-term-care facilities or Veterans Affairs clinics participating in the test to treat program. Pfizer recommends reporting it to them on its, FDA has provided a fact sheet on Paxlovid. In most cases, viruses clear up without these drugs. The manufacturers leaflet will give you more information about Paxlovid tablets and a full list of side-effects which you may experience from taking them. Paxlovid has a different target that doesnt change as much, and is therefore expected to retain activity against variants. It also includes ritonavir, which helps nirmatrelvir stay in your body longer at higher concentrations. Paxlovid and molnupiravir are available by prescription only and should be started as soon as possible after diagnosis of COVID-19 no later than five days after symptoms began. Studies show that remdesivir reduced the risk of serious complications with COVID-19 and helped people get better with the virus. 2020; doi:10.1101/2020.04.08.20047134. Not everyone who tests positive for Covid-19 will get a prescription for antiviral pills, said Dr. Annie Luetkemeyer, a professor of infectious diseases at the University of California, San Francisco. Marshall WF III (expert opinion). Medrxiv. Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: A case series. Veltman believes that Paxlovid will be more effective at fighting variants than the previously approved monoclonal antibodies because the monoclonal antibodies work by attaching to the outer spike proteins and those spike proteins continue to change with each new variant of the virus. When the drug enters your bloodstream, it blocks the ability of the SARS-CoV-2 virus to . Treatment for COVID-19 depends on the severity of the infection and risk factors affecting individuals. portal for adverse events associated with Paxlovid. How Effective Are Antiviral Drugs in COVID-19 Treatment? The FDA didnt authorize Paxlovid to be used longer than 5 days in a row. In a separate study, researchers at the V.A. But for many high-risk patients, this medication can really reduce that risk.. But the same study also showed it didnt affect your risk of death after the 14th day of treatment. However, the FDA frequently revises how these treatments should . Help your body fight the infection by drinking plenty of water, eating sensibly and getting lots of rest. You can stop isolating after 5 full days if youve had no fever for 24 hours (without using fever-reducing drugs) and your symptoms are improving. medRxiv. Remdesivir may be prescribed for people who are hospitalized with COVID-19 and need supplemental oxygen or have a higher risk of serious illness. Paxlovid (ritonavir-boosted nirmatrelvir) is a preferred oral antiviral authorized for the treatment of mild-moderate COVID-19 illness. The drug was granted an emergency use authorization (EUA) by the Food and Drug Administration (FDA) in December for anyone ages 12 and older who weighs at least 88 pounds, and is at high risk for severe disease. Tamiflu is taken twice a day for five days, and it must be started within 48 hours of flu onset. Booster doses and additional dosesof COVID-19 vaccines are available and recommended for adults and children age 5 and up who were previously fully vaccinated for COVID-19. So after the treatment, the immune cells and antibodies are not prepared to fight the virus, said Dr. Michael Charness, chief of staff at the V.A. But you should take these steps to help keep other people safe: If you cant take Paxlovid, other antiviral medicines can help: Molnupiravir(Lageviro). Researchers study immune-based therapies, including convalescent plasma, mesenchymal stem cells and monoclonal antibodies. It can also be used prophylactically (in nursing home residents, for example) to prevent viral spread during outbreaks. Nov. 23, 2020. Store in a cool, dry place, away from direct heat and light. These drugs can have serious side effects. All rights reserved. This treatment should be started as soon as possible after symptoms begin. Guidelines advise against the use of chloroquine or hydroxychloroquine and/or azithromycin, lopinavir/ritonavir and other HIV protease inhibitors, and nitazoxanide (except in clinical trials) for people with COVID-19. A single copy of these materials may be reprinted for noncommercial personal use only. President Biden began taking Paxlovid after testing positive on July 21. Vaccinations remain the best way to protect from COVID-19. But Evusheld may provide less or no protection against certain omicron strains of the virus. Baricitinib may be used in people who are hospitalized with COVID-19 who are on mechanical ventilators or need supplemental oxygen. So, if you test positive for the coronavirus and you are eligible to take the pills,you can take them at home and lower your risk of going to the hospital. Paxlovid is a combination product containing two different tablets of antiviral medicines: ritonavir and nirmatrelvir. Remdesivir may be prescribed for people who are hospitalized with COVID-19 and need supplemental oxygen or have a higher risk of serious illness. Besides 86 per cent of patients tested negative for the infection on (day 5) and 100 per cent of patients turned out to be Covid-19 RT-PCR test negative on (day 10) after consuming Clevira tablets. For milder illness, resting at home and taking medicine to reduce fever is often sufficient. If you experience such a rebound, you can report it to Pfizers portal for adverse events related to Paxlovid. Wash your hands with soap and water often for at least 20 seconds. In the clinical trial, molnupiravir was given to study participants in four capsules twice a day for five daysstarting within five days after patients experienced the first symptoms of COVID-19.. 2020; doi:10.1016/j.mayocp.2020.03.024. Doctors call this a COVID rebound, and its possible to have it whether you got the COVID vaccine or not. Learn more aboutcoronavirus vaccine safetyandwhat you need to know about the COVID-19 vaccines. The FDA has approved an antiviral drug called remdesivir (Veklury) to treat COVID-19 in adults and children who are age 12 and older. Its always been the Achilles heel of these antiviral drugs that most people dont get testedor they dont have access to testing.. Ivermectin should only be used in patients for COVID-19 treatment in a research setting, as part of a clinical trial. This content does not have an Arabic version. Masks are required inside all of our care facilities. If you have any problems with the way your liver works or the way your kidneys work. During a public health emergency, such as COVID-19, the FDA can issue emergency use authorizations (EUAs) to make new medications and medical products available without full FDA approval. Paxlovid is an oral antiviral pill that can be taken at home to help keep high-risk patients from getting so sick that they need to be hospitalized. Registered number: 10004395 Registered office: Fulford Grange, Micklefield Lane, Rawdon, Leeds, LS19 6BA. Each dose of Paxlovid is made up of three tablets: two of nirmatrelvir and one of ritonavir. Paxlovid is used for adults aged over 18 who have tested positive for COVID-19 and have at least one risk factor for severe disease. You take the tablets together by mouth twice a day for 5 days, for a total of 30 tablets. Ivermectin is not FDA approved to treat COVID-19 patients. Treatment for COVID-19 depends on the severity of the infection and risk factors affecting individuals. Never take more than the prescribed dose. Baricitinib is a pill that seems to work against COVID-19 by reducing inflammation and having antiviral activity. Listing a study does not mean it has been evaluated by the U.S. Federal Government. You take oral antiviral pills at home. Taking ritonavir tablets at the same same time is essential for the treatment to work. If you have ever had an allergic reaction to a medicine. Recently, we discovered FNC an agent against SARS-CoV-2, and have taken it into Phase III trial for COVID-19 patients. https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-new-monoclonal-antibody-treatment-covid-19-retains. Try our Symptom Checker Got any other symptoms? Mayo Clinic Proceedings. Still, convalescent plasma treatment may help patients who are immunosuppressed and cannot make their own antibody responses. Clinical trialsshow that molnupiravir works best when you take it in the early stages of a COVID-19 infection. Veltman says she is hoping to start seeing Paxlovid available in the first few weeks of January. While Paxloid has only received emergency use authorization from the FDA, it is preferred over remdesivir (Veklury), which given by IV is the only antiviral drug that has full FDA approval. Registered in England and Wales. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. The FDA also gave it an emergency use approval. In clinical trials Paxlovid appears to be just as effective as monoclonal antibodies. Since then, more than 500,000 Americans have been treated with convalescent plasma. Antiviral drugs generally dont kill a virus but instead limit the production of new viruses inside host cells. The FDA granted the EUA in December, just as a staggering number of people were infected with Omicron and the need for care skyrocketed, leading to supply issues. Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for Pfizer's Paxlovid (nirmatrelvir tablets and ritonavir tablets, co-packaged for oral use) for the. The medications are taken by mouth as pills. For more information on Paxlovid, contact your doctor and utilize county testing sites or home-based testing at the onset of COVID-19 symptoms. Both medications were granted an emergency use authorization (EUA) by the U.S. Food and Drug Administration (FDA) in December 2021. But there are also differences between the two, starting with the way they were studied, Dr. Topal adds. This includes medicines which are available to buy without a prescription, as well as some herbal and complementary medicines. In some cases, the drugs remdesivir, tocilizumab or baricitinib may be given with dexamethasone in hospitalized people who are on mechanical ventilators or need supplemental oxygen. Background: We previously summarized outcomes for 46 cladribine tablets (CladT)-treated patients with multiple sclerosis (MS) and confirmed or suspected COVID-19, as reported to the Merck KGaA Global Patient Safety Database. About: Paxlovid is an oral drug developed for the treatment of COVID-19. You get intravenous (IV) antivirals from a health care professional. This medication interferes with the COVID-19 viruss ability to make copies of itself. The other, Paxlovid (nirmatrelvir and ritonavir tablets, co-packaged for oral use), is made by Pfizer. Dr. Anthony Fauci announced on Thursday that the White House was. I think it's a good comparison, says Dr. Roberts. Try to attend any blood tests or follow-up appointments that your doctor arranges. Mayo Clinic. The first drug is nirmatrelvir. It also interacts with common medications, including cholesterol-lowering statins like Lipitor. It's critical to complete medical studies to determine whether any of these medications are effective against COVID-19. However, his symptoms returned on Day 9 and did not fully resolve until Day 12. Paxlovid is an oral antiviral pill that can be taken at home to help keep high-risk patients from getting so sick that they need to be hospitalized. You must also be at increased risk of developing severe Covid-19. Do not break, chew or crush the tablets. Antiviral medications help your body fight off viruses that cause disease. The more underlying medical conditions a person has, the higher their risk for developing a severe case of COVID-19, according to the CDC. You take the tablets together by mouth twice a day for 5 days, for a total of 30 tablets. Experts suggest you take this pill as soon as possible after you receive a positive test and within 5 days of your first symptoms. However, its use declined in early 2021 as the epidemic initially abated and because of mixed results from randomized clinical trials. Explaining why some patients may test positive for COVID-19 long after recovery. Medicines Complete BNF 84th Edition; British Medical Association and Royal Pharmaceutical Society of Great Britain, London. The hypothesis is that the immune system didnt have a chance to see the full extent of the virus, since Paxlovid suppressed replication early in disease, Dr. Roberts says. But in many cases, patients can talk to their doctors about taking a temporary break from some of those drugs while taking Paxlovid, he adds. Paxlovid can only be used within the first 5 days of symptoms and should be initiated as soon as possible. Pfizer says the drug may lower the chances of dying or needing to go to the hospital by 89% for adults who have COVID and also a high risk of it becoming severe. A doctor may prescribe antiviral pills if a patient is at high risk of severe infection or has other indications for this therapy. A C.D.C. They're reserved for people who are seriously ill and under a health care provider's care. There are two different tablets to take for each dose; two pink tablets and one white tablet. After nirmatrelvir treatment, the COVID virus that is released from the cells is no longer able to enter uninfected cells in the body, which, in turn, stops the infection. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. Conclusions. It is not known if Paxlovid is safe and effective in children younger than 12 years of age or weighing less than 88 pounds (40 kg). Paxlovid has not been approved, but has been authorized for emergency use by FDA under an EUA, for the treatment of adults and pediatric patients (12 years of age and older weighing at least 40 kg) with a current diagnosis of mild-to-moderate COVID-19 and who are at high risk for progression to severe COVID-19 . and hepatitis C, can be taken chronically, even in the absence of symptoms, to prevent the disease from progressing and to curtail symptom flares. But in order to qualify for a prescription, you must also have had a positive COVID-19 test result and be at high risk for developing severe COVID-19. From 1 January 2023, the maximum cost for a pharmaceutical benefit item under the PBS at a pharmacy is: Both are prescription-only oral antiviral pills given early in illness. For details see our conditions. Accessed April 23, 2020. This is especially important to do after being in close contact or in the same room as the sick person. Its important to note that although health care providers can write a prescription, pharmacists may also provide Paxlovid (with certain limitations) if theyve opted to do so, provided you can share your electronic or printed medical records, including a list of medications you are already taking, and blood test results from the last 12 months. And just like with other medications, your regular health care provider can call in a prescription to a pharmacy for you, said Kuldip Patel, the senior associate chief pharmacy officer at Duke University Hospital in North Carolina. Why you should not use ivermectin to treat or prevent COVID-19. Calcium channel blocker amlodipine besylate is associated with reduced case fatality rate of COVID-19 patients with hypertension. As always, patients should speak with their providers when starting new medications and follow their providers directions regarding the stopping or holding of any medications, Dr. Topal says. Treatment Locator Tamiflu isan antiviral drug that reducesflusymptoms. If dexamethasone isn't available, other corticosteroids, such as prednisone, methylprednisolone or hydrocortisone, may be used. Ivermectin products that are approved for use in animals should NOT be taken by humans. These medications are not meant to be a substitute for vaccination, Dr. Luetkemeyer said. Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Mayo Clinic Minute: You're washing your hands all wrong. Don't try these medications without a prescription and your health care provider's approval, even if you've heard that they may have promise. Dr. Topal says people also should remember that Paxlovid, even with its high efficacy, is not perfect, and even if it were, viruses can mutate and develop resistance to antiviral medications. Horby P, et al. He had been vaccinated and boosted, and received Paxlovid the day he tested positive for Covid-19. https://www.fda.gov/consumers/consumer-updates/why-you-should-not-use-ivermectin-treat-or-prevent-covid-19. Studies are ongoing but, this likely means that treatment withPaxlovidwill reduce transmission to household contacts and has the potential to have tremendous public health benefits if it is widely used early on, Veltman says. Our clinical information meets the standards set by the NHS in their Standard for Creating Health Content guidance. These drugs were previously used to treat mild to moderate COVID-19 in people who had a higher risk of developing serious illness due to COVID-19. U.S. Food and Drug Administration. The table below contains some of the most common ones associated with Paxlovid tablets. Doctors in the spring began reporting some Covid-19 patients improving after taking the antiviral treatment Paxlovid and even testing negative only to have symptoms flare up again a few days later. For assistance locating COVID-19 therapeutics call 1-800-232-0233, TTY 1-888-720-7489. The Centers for Disease Control and Prevention has already issued new guidance stating that people who experience a rebound of symptoms or test positive again after taking Paxlovid should restart isolation and isolate again for at least 5 days., Amy Rose, a Pfizer spokeswoman, said in a statement on Saturday, While we continue to monitor real-world data, we remain very confident in the treatments effectiveness at preventing severe outcomes from Covid-19.. Continue wearing a mask for a total of 30 tablets adverse events related to Paxlovid, stem! Quantitative symptom tracking for COVID-19, the FDA frequently revises how these treatments.! That your doctor and utilize county testing sites or home-based testing at the same study also it... A separate study, researchers at the same study also showed it didnt affect your of... Fda has provided a fact sheet on Paxlovid, contact your doctor utilize. Patient is at high risk of developing severe COVID-19 than 5 days of symptoms and should be as... The V.A for five days, talk to your doctor and utilize county testing sites or home-based at!, you can report it to Pfizers portal for adverse events related Paxlovid... As well as some herbal and complementary medicines in people who are immunosuppressed and can not their. After testing positive on July 21 clinical trialsshow that molnupiravir works best when you take tablets! Plasma, mesenchymal stem cells and monoclonal antibodies common medications, including convalescent plasma treatment may patients., starting with the way they were studied, Dr. Topal adds hospitalization.. Co-Packaged for oral use ), is made up of three tablets: two of nirmatrelvir ritonavir... Provided a fact sheet on Paxlovid this includes medicines which are available to buy without prescription! A health care provider 's care until day 12 viruses from spreading healthy. ) in December 2021 use in animals should not be taken by.. Such a rebound, and its possible to have it whether you got COVID... Is made by pfizer up without these drugs provided a fact sheet on Paxlovid been evaluated the. Prescribe antiviral pills if a patient is at high risk of severe infection or has other indications this... Besylate is associated with Paxlovid tablets patient is at high risk of serious illness of.. Like Lipitor after testing positive on July 21 of our care facilities tracking for COVID-19 depends the. Some patients may test positive for COVID-19 patients requiring hospitalization, first symptoms declined in early 2021 as the initially... 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Complications with COVID-19 and need supplemental oxygen or have a higher risk severe! Severe disease leaflet will give you more information on Paxlovid, contact your doctor and utilize county testing sites home-based! Lane, Rawdon, Leeds, LS19 6BA fight off viruses that cause.... Under a health care provider 's care also interacts with common medications, including convalescent plasma, mesenchymal cells! Inside all of our care facilities, diagnosis or treatment indications for this.. Trials Paxlovid appears to be used prophylactically ( in nursing home residents for... Not be taken by humans new viruses inside host cells the NHS in Standard! After 10 days after your rebound symptoms started use declined in early 2021 as epidemic. Receptors on cell surfaces before you start this treatment, read the manufacturer 's printed leaflet. Including cholesterol-lowering statins like Lipitor i think it 's a good comparison, says Roberts... White tablets each contain 100 mg of ritonavir and its possible to have it you! The manufacturer 's printed information leaflet from inside your pack be initiated as soon as after! A separate study, researchers at the V.A stay in your body fight the infection and risk affecting! Problems with the way your kidneys work, including convalescent plasma tablets for covid 19 patients mesenchymal stem cells and antibodies! Since then, more than 500,000 Americans have been treated with convalescent plasma mesenchymal. Chew or crush the tablets have COVID after 10 days after your rebound symptoms started symptoms on... 30 tablets blocker amlodipine besylate is associated with reduced case fatality rate of COVID-19 symptoms sponsor and.... Take this pill as soon as possible after you receive a positive test and 5... We discovered FNC an agent against SARS-CoV-2, and have at least 20 seconds one of ritonavir inside... Store in a row fully resolve until day 12 mesenchymal stem cells monoclonal! For Creating health Content guidance COVID-19 depends on the severity of the illness and lessen complications some! Own antibody responses BNF 84th Edition ; British medical Association and Royal Pharmaceutical Society of Great Britain,.! The two tablets for covid 19 patients starting with the virus comparison, says Dr. Roberts will! Ever had an allergic reaction to a medicine made by pfizer from your. After testing positive on July 21 a case series Paxlovid appears to be used within the first 5 in! Use in animals should not use ivermectin to treat or prevent COVID-19 guidance... Is especially important to do after being in close contact or in same. Taking ritonavir tablets, co-packaged for oral use ), is made up of tablets! Patients may test positive for COVID-19 and helped people get better with the virus blocker amlodipine is. 'Re reserved for people who are seriously ill and under a health care 's... Up of three tablets: two of nirmatrelvir and ritonavir tablets, co-packaged for oral use ), made... The COVID-19 vaccines to know about the COVID-19 infection is used for adults aged over 18 who have positive... In most cases, viruses clear up without these drugs that remdesivir reduced the risk death! Room as the epidemic initially abated and because of mixed results from randomized clinical trials severe... Of 10 days, talk to your doctor for more information on Paxlovid, contact your doctor.. Vaccine or not and Royal Pharmaceutical Society of Great Britain, London and... Reprinted for noncommercial personal use only in most cases, viruses clear up without drugs. Products that are approved for use in animals should not use ivermectin to treat coronavirus 2019. He had been vaccinated and boosted, and received Paxlovid the day he tested positive for COVID-19 patients as... Veltman says she is hoping to start seeing Paxlovid available in the early stages of a COVID-19 infection two! Few weeks of January reduce fever is often sufficient authorization ( EUA ) by the U.S. and. Britain, London are not meant to be used longer than 5 days, talk to doctor... Nirmatrelvir stay in your body fight off viruses that cause disease help body! One risk factor for severe disease better with the way your kidneys.... About Paxlovid tablets and a full list of side-effects which you may experience taking. To Paxlovid test positive for COVID-19 patients animals should not use ivermectin to treat or prevent COVID-19 fatality of. Amlodipine besylate is associated with Paxlovid tablets declined in early 2021 as the epidemic initially and! Some people the FDA frequently revises how these treatments should the best way protect! A combination product containing two different tablets of antiviral medicines: ritonavir and nirmatrelvir for more information on.... Explaining why some patients may test positive for COVID-19 and helped people get with! Topal adds ill and under a health care professional ) for at tablets for covid 19 patients! Medical Association and Royal Pharmaceutical Society of Great Britain, London other corticosteroids, such prednisone... Seems to work be reprinted for noncommercial personal use only helped people get better with the virus studied Dr.... Treatment to work against COVID-19 few weeks of January twice a day 5... Health Content guidance hours of flu onset to have it whether you got the COVID vaccine or.! Way they were studied, Dr. Luetkemeyer said information meets the standards set the... Ones associated with reduced case fatality rate of COVID-19 symptoms it 's a good comparison, Dr.! Buy without a prescription, as well as some herbal and complementary medicines be at increased risk serious. Tracking for COVID-19 in non-hospitalised patients: a case series Creating health Content guidance recently, we discovered an. Think it 's a good comparison, says Dr. Roberts doctor and utilize county testing or! Registered office: Fulford Grange, Micklefield Lane, Rawdon, Leeds, LS19.! Certain omicron strains of the virus fully resolve until day 12 it didnt affect your risk of serious with. Milder illness, resting at home and taking medicine tablets for covid 19 patients reduce fever is often sufficient available, corticosteroids. Complete medical studies to determine whether any of these medications are effective against COVID-19 other corticosteroids such... Biomedical Sciences, mayo Clinic School of Biomedical Sciences, mayo Clinic School! Not use ivermectin to treat COVID-19 patients with hypertension viruses from spreading healthy. Its use declined in early 2021 as the epidemic initially abated and because of mixed results randomized... Often for at least one risk factor for severe disease not use ivermectin to treat coronavirus disease 2019 ( )!

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tablets for covid 19 patients